ReGena-Vet Laboratories, LLC

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extensor postural thrust are often deficient.  The degree of proprioceptive dysfunction (knuckling under of rear paw) is usually greater than the degree of motor dysfunction. There can be muscle atrophy (as measured below right). Pain perception is usually normal and there are no signs of lower motor neuron abnormalities.  When present, these clinical findings are highly suggestive of degenerative myelopathy. However, a slowly progressing disc extrusion or a slow growing tumor with compression of the spinal cord can also have similar neurological signs. DM must be differentiated

Ongoing Clinical Trials 5

radiographically from type II (slow) disc protrusions and spinal neoplasia or the presence of tumors in the cord.  This is done by using survey radiography, myelography and MRI. CSF fluid is usually collected to exclude the presence of inflammatory diseases. ReGena-Vet Labs has tested their

MSCs in several different breeds with DM with encouraging results. Of six German/Belgian Shepherd Dogs tested, all tolerated the treatment very well. Most exhibited signs of improvement (similar to Outcome 3) or appeared to have an arrest of the progression of clinical signs (Outcome 2) as on page 2. DM is a very difficult disease to quantify beneficial effects, but comments from owners indicated all felt there was improvement with minimal side effects. We anticipate result that MSC treatment will give a response in GSDs that is somewhere between Outcome “2 and “3”. To date, we have not seen a similar response in Pembroke Welch Corgis. It is clear from our limited results that better effects are found in animals that are treated early in the course of the disease.  Again, this treatment is still a research project and not yet “standard of care” veterinary medicine.